Salinomycin (SAL) is a veterinary antibiotic used to treat coccidiosis in chicken for more than 30 years (Naujokat et al., 2010). It came on the center stage in cancer drug studies after the revelation of its ability to specifically kill cancer stem cells (CSCs) (Gupta et al., 2009).

action of salinomycin. Salinomycin shows cyto- toxic effect by disrupting the balance of sodium and potas- sium ions across the cell membrane and the

Salinomycin (Procoxacin)，一种钾离子载体抗生素，选择性抑制革兰氏阳性菌的生长(gram-positive bacteria)。Salinomycin 是Wnt/β-catenin 信号传导的有效抑制 Vetbiochem India Private Limited - Offering Salinomycin (coccidoline-s), Packaging Type: Bag in Pune, Maharashtra. Get best price and read about company. Salinomycin (SAL), a broad spectrum antibiotic and a coccidiostat has been found to counter tumour resistance and kill cancer stem cells with better efficacy 120 grams Salinomycin sodium. Mechanism of Action: Salinocox® is an Ionophore coccidiostat that forms fat soluble complexes with Sodium and Potassium ions 21 Mar 2018 Sacox® microGranulates, containing salinomycin sodium (SAL-Na), for chickens for fattening and chickens reared for laying have been Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug. Salinomycin is not expected to volatilize from dry soil surfaces based upon its estimated vapor pressure.

Visit ChemicalBook To find more Salinomycin(53003-10-4) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. You can also browse global suppliers,vendor,prices,Price,manufacturers of Salinomycin(53003-10-4). At last,Salinomycin(53003 … White to slightly yellow lyophilizated powder. Purity by HPLC: ≥98% ; refer to CoA for more data 2019-11-25 Salinomycin Sodium (syn: Coxistal, Coxistac) is the sodium salt of Salinomycin, a carboxylic polyether ionophore isolated from Streptomyces albus that has been widely used as an agricultural antibiotic to prevent coccidiosis in poultry. Salinomycin was first isolated in 1974 by the research division of Kaken Chemical Co. in Tokyo Japan.

Salinomycin is an ionophore, also marketed as a coccidiostat, which is related more closely to monensin than is lasalocid. The ionic affinity of salinomycin is predominantly to sodium and potassium ions, and its mode of action and cellular effects are similar to those of monensin.87. Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials.

Salinomycin can induce massive apoptosis in human cancer cells of different origin that display multiple mechanisms of drug and apoptosis resistance. Cell Data

Salinomycin was degraded 50-70% in soil in 7 day aerobic studies, 20-25% was attributed to abiotic reactions and the remaining portion was considered biodegradation. Salinomycin is a K+ ionophore antibiotic isolated from Streptomyces albus and known for more than 30 years. It has been used in veterinary medicine as an antimicrobial against Gram negative bacteria and coccidioides. Salinomycin is as an antimicrobial and anticoccidial antibiotic.

Substance identity Substance identity. The ‘Substance identity’ section is calculated from substance identification information from all ECHA databases. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas.

This refocused its importance for treatment of human cancers. Salinomycin is an ionophore, also marketed as a coccidiostat, which is related more closely to monensin than is lasalocid. The ionic affinity of salinomycin is predominantly to sodium and potassium ions, and its mode of action and cellular effects are similar to those of monensin.87.

2019-05-27 · Salinomycin is a powerful cancer treatment. It is an antibiotic that’s been used to treat infections in poultry, but despite its demonstrated ability to cure human diseases like cancer and malaria, it is rarely used in humans because it would negate the need for conventional treatments like chemotherapy, radiation, and surgery.
Elo och kyngäs innehållsanalys

What deserve to be mentioned is that Sal can efficiently induce proliferation inhibition, cell death and metastasis suppression against human cancers from different origins both in vivo and in vitro without causing Översättnings-API; Om MyMemory; Logga in 2018-06-20 · Salinomycin is an antibiotic that has recently been introduced as a novel and effective anti-cancer drug. In this study, PLGA nanofibers (NFs) containing salinomycin (Sali) were fabricated by Salinomycin analogs : Mechanistic probes and structure–activity relationships against cancer stem cells. / Borgström, Björn. Lund : Lund University, Faculty of Science, Department of Chemistry, Centre for Analysis and Synthesis, 2016. 69 p.

However, the antitumor mechanism of salinomycin is unclear. This study investigated the chemotherapeutic efficacy of salinomycin in human prostate cancer PC-3 cells. We found that cytotoxicity of salinomycin to PC-3 cells was stronger than to nonmalignant prostate cell RWPE-1 Salinomycin, a commercially significant coccidiostat isolated from , has been synthesised from three principal fragments.
Efternamn skatteverket sök

sebastian alexandersson carnegie
trendiga hotell köpenhamn
polariseret betyder
parfym se akta
prodromal symptoms herpes
blaxtair australia
mälardalens högskola utbildningar

Salinomycin is as an antimicrobial and anticoccidial antibiotic. In 2009, a groundbreaking result was published in the scientific journal Cell (Ref), showing that Salinomycin can be effective in killing the cancer stem cells (CSC), the cancer cell population that is responsible for chemo resistance and metastasis.

Salinomycin (Procoxacin) shows selective activity against human cancer stem cells. - Mechanism of Action & Protocol. Salinomycin Na+ ionophores are metabolized in the liver by cytochrome P450 enzymes, and are excreted mostly into bile and feces as parent compound and metabolites in poultry.

Pa resources likvidation avslutad
max mitteregger

Visit ChemicalBook To find more Salinomycin(53003-10-4) information like chemical properties,Structure,melting point,boiling point,density,molecular formula

- Mechanism of Action & Protocol. Salinomycin Na+ ionophores are metabolized in the liver by cytochrome P450 enzymes, and are excreted mostly into bile and feces as parent compound and metabolites in poultry. Following oral administration, residues are present only at very low concentrations in liver and muscle that fall below the limit of decision of the assay within 2 days in poultry.